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That does not, not surprisingly, mean that such ADRs will happen, basically that there is insufficient knowledge to evaluate whether or not they do occur.Costa and colleagues [178] have advised that PEA was capable to lower mechanical allodynia and thermal hyperalgesia subsequent sciatic nerve constriction in mice, by way of an motion upon receptor
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2015). These scientific studies, taken together, counsel that, Though a immediate activation of GPR55 or PPAR?? occurs, PEA can make its anti?inflammatory motion during the gut also by using oblique activation of CB1 and CB2 receptors, probably as a result of the flexibility of the compound to potentiate the action of endocannabinoids at these rece
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